[HTML][HTML] IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene Expression*♦
Y Huang, T Li, DC Sane, L Li - Journal of Biological Chemistry, 2004 - ASBMB
Being one of the key kinases downstream of Toll-like receptors, IRAK1 has initially thought
to be responsible for NFκB activation. Yet IRAK1 knock-out mice still exhibit NFκB activation
upon lipopolysaccharide (LPS) challenge, suggesting that IRAK1 may play other un-
characterized function. In this report, we show that IRAK1 is mainly involved in Stat3
activation and subsequent interleukin-10 (IL-10) gene expression. Splenocytes from IRAK1-
deficient mice fail to exhibit LPS-induced Stat3 serine phosphorylation and IL-10 gene …
to be responsible for NFκB activation. Yet IRAK1 knock-out mice still exhibit NFκB activation
upon lipopolysaccharide (LPS) challenge, suggesting that IRAK1 may play other un-
characterized function. In this report, we show that IRAK1 is mainly involved in Stat3
activation and subsequent interleukin-10 (IL-10) gene expression. Splenocytes from IRAK1-
deficient mice fail to exhibit LPS-induced Stat3 serine phosphorylation and IL-10 gene …