The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
AP Robinson, CT Harp, A Noronha, SD Miller - Handbook of clinical …, 2014 - Elsevier
While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to
develop therapeutic strategies that limit disease progression and eventually lead to effective
treatments for the human disease. Several different models of MS exist, but by far the best
understood and most commonly used is the rodent model of experimental autoimmune
encephalomyelitis (EAE). This model is typically induced by either active immunization with …
models are essential in understanding the induction and pathogenesis of the disease and to
develop therapeutic strategies that limit disease progression and eventually lead to effective
treatments for the human disease. Several different models of MS exist, but by far the best
understood and most commonly used is the rodent model of experimental autoimmune
encephalomyelitis (EAE). This model is typically induced by either active immunization with …