IL-9 signaling affects central nervous system resident cells during inflammatory stimuli
X Ding, F Cao, L Cui, B Ciric, GX Zhang… - … and molecular pathology, 2015 - Elsevier
Abstract Interleukin (IL) 9, a dominant cytokine in Th9 cells, has been proven to play a
pathogenic role in experimental autoimmune encephalomyelitis (EAE), an animal model of
multiple sclerosis (MS), by augmenting T cell activation and differentiation; however,
whether IL-9 signaling affects central nervous system (CNS)-resident cells during CNS
autoimmunity remains unknown. In the present study, we found that the IL-9 receptor (IL-9R)
was highly expressed in astrocytes, oligodendrocyte progenitor cells (OPCs) …
pathogenic role in experimental autoimmune encephalomyelitis (EAE), an animal model of
multiple sclerosis (MS), by augmenting T cell activation and differentiation; however,
whether IL-9 signaling affects central nervous system (CNS)-resident cells during CNS
autoimmunity remains unknown. In the present study, we found that the IL-9 receptor (IL-9R)
was highly expressed in astrocytes, oligodendrocyte progenitor cells (OPCs) …