Monocytes in multiple sclerosis: phenotype and cytokine profile
M Kouwenhoven, N Teleshova, V Özenci… - Journal of …, 2001 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease characterised by immune
abnormalities in the central nervous system (CNS) as well as systemically. Activated, blood-
borne monocytes are abundant in MS lesions, the properties of circulating monocytes are
incompletely known. To delineate phenotype and levels of cytokine secreting monocytes in
MS patients' blood, ELISPOT assays were used for detection and enumeration of monocytes
secreting the cytokines IL-6, IL-12, TNF-α and IL-10. In parallel, the expression by …
abnormalities in the central nervous system (CNS) as well as systemically. Activated, blood-
borne monocytes are abundant in MS lesions, the properties of circulating monocytes are
incompletely known. To delineate phenotype and levels of cytokine secreting monocytes in
MS patients' blood, ELISPOT assays were used for detection and enumeration of monocytes
secreting the cytokines IL-6, IL-12, TNF-α and IL-10. In parallel, the expression by …