Nucleocytoplasmic trafficking is an essential and responsive cellular mechanism that directly
affects cell growth and proliferation, and its potential to address metabolic challenge is
incompletely defined. Ceramide is an antiproliferative sphingolipid found within vascular
smooth muscle cells in atherosclerotic plaques, but its mechanism of action remains unclear.
The hypothesis that ceramide inhibits cell growth through nuclear transport regulation was
tested. In smooth muscle cells, exogenously supplemented ceramide inhibited classical …