[HTML][HTML] Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes
H Nagasaki, T Kondo, M Fuchigami, H Hashimoto… - FEBS letters, 2012 - Elsevier
H Nagasaki, T Kondo, M Fuchigami, H Hashimoto, Y Sugimura, N Ozaki, H Arima, A Ota…
FEBS letters, 2012•ElsevierIn this study we aimed to identify the physiological roles of G protein-coupled receptor 84
(GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific
ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-
L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably
enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin
mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 …
(GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific
ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-
L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably
enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin
mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 …
In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.
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