The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking
C Venkataraman, F Kuo - Immunology letters, 2005 - Elsevier
The orphan G-protein coupled receptor, GPR84 is highly expressed in the bone marrow,
and in splenic T cells and B cells. In this study, GPR84-deficient mice were generated to
understand the biological function of this orphan receptor. The proliferation of T and B cells
in response to various mitogens was normal in GPR84-deficient mice. Interestingly, primary
stimulation of T cells with anti-CD3 resulted in increased IL-4 but not IL-2 or IFN-γ production
in GPR84−/− mice compared to wild-type mice. Augmented IL-4 production in GPR84 …
and in splenic T cells and B cells. In this study, GPR84-deficient mice were generated to
understand the biological function of this orphan receptor. The proliferation of T and B cells
in response to various mitogens was normal in GPR84-deficient mice. Interestingly, primary
stimulation of T cells with anti-CD3 resulted in increased IL-4 but not IL-2 or IFN-γ production
in GPR84−/− mice compared to wild-type mice. Augmented IL-4 production in GPR84 …