[HTML][HTML] Insulin/IGF‐1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function
RW Hunter, I Hers - Journal of Thrombosis and Haemostasis, 2009 - Elsevier
Objectives: As platelets express both insulin and insulin‐like growth factor‐1 (IGF‐1)
receptors, their subunits may randomly heterodimerize to form insulin/IGF‐1 receptor
hybrids, which avidly bind IGF‐1, but not insulin. This study investigated the possibility that
platelets express hybrid receptors, which may affect insulin action on platelet function.
Methods: Platelets were incubated with insulin and IGF‐1. Expression and phosphorylation
of insulin/IGF‐1 receptors was determined by western blotting of immunoprecipitates, and …
receptors, their subunits may randomly heterodimerize to form insulin/IGF‐1 receptor
hybrids, which avidly bind IGF‐1, but not insulin. This study investigated the possibility that
platelets express hybrid receptors, which may affect insulin action on platelet function.
Methods: Platelets were incubated with insulin and IGF‐1. Expression and phosphorylation
of insulin/IGF‐1 receptors was determined by western blotting of immunoprecipitates, and …