[HTML][HTML] CHIP controls the sensitivity of transforming growth factor-β signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
H Xin, X Xu, L Li, H Ning, Y Rong, Y Shang… - Journal of Biological …, 2005 - ASBMB
Transforming growth factor-β (TGF-β) signaling is critical in a variety of biological processes
such as cell proliferation, differentiation, and apoptosis. TGF-β signaling is mediated by a
group of proteins including TGF-β receptors and Smads. It is known that different cells can
exhibit different sensitivities to TGF-β. Several molecular mechanisms, such as the
differential expression of the receptor levels, have been suggested as contributing to these
differences. Here, we report evidence for a novel mechanism of regulating TGF-β sensitivity …
such as cell proliferation, differentiation, and apoptosis. TGF-β signaling is mediated by a
group of proteins including TGF-β receptors and Smads. It is known that different cells can
exhibit different sensitivities to TGF-β. Several molecular mechanisms, such as the
differential expression of the receptor levels, have been suggested as contributing to these
differences. Here, we report evidence for a novel mechanism of regulating TGF-β sensitivity …