[HTML][HTML] Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-β signaling
Y Nagano, KJ Mavrakis, KL Lee, T Fujii… - Journal of Biological …, 2007 - ASBMB
Transforming growth factor-β (TGF-β) signaling is controlled by a variety of regulators that
target either signaling receptors or activated Smad complexes. Among the negative
regulators, Smad7 antagonizes TGF-β signaling mainly through targeting the signaling
receptors, whereas SnoN and c-Ski repress signaling at the transcriptional level through
inactivation of Smad complexes. We previously found that Arkadia is a positive regulator of
TGF-β signaling that induces ubiquitin-dependent degradation of Smad7 through its C …
target either signaling receptors or activated Smad complexes. Among the negative
regulators, Smad7 antagonizes TGF-β signaling mainly through targeting the signaling
receptors, whereas SnoN and c-Ski repress signaling at the transcriptional level through
inactivation of Smad complexes. We previously found that Arkadia is a positive regulator of
TGF-β signaling that induces ubiquitin-dependent degradation of Smad7 through its C …