Reversible regulation of the retinoblastoma protein/E2F-1 pathway during “reverse cardiac remodelling” after ventricular unloading
J Wohlschlaeger, KJ Schmitz, A Takeda… - The Journal of heart and …, 2010 - Elsevier
BACKGROUND: Cyclin D1, the retinoblastoma (Rb) protein, and the E2F transcription
factors are involved in the pathogenesis of cardiac hypertrophy. Cyclin D1/cdk4 complexes,
by phosphorylation, inactivate Rb, thereby abrogating its growth-inhibitory effect. Ventricular
unloading is associated with reversible regulation of numerous cardiomyocyte molecular
systems and decreased hypertrophy. Accordingly, the hypothesis whether the Rb/E2F-1
pathway is altered by ventricular unloading was tested, and correlations with the cyclin D1 …
factors are involved in the pathogenesis of cardiac hypertrophy. Cyclin D1/cdk4 complexes,
by phosphorylation, inactivate Rb, thereby abrogating its growth-inhibitory effect. Ventricular
unloading is associated with reversible regulation of numerous cardiomyocyte molecular
systems and decreased hypertrophy. Accordingly, the hypothesis whether the Rb/E2F-1
pathway is altered by ventricular unloading was tested, and correlations with the cyclin D1 …