[HTML][HTML] Activation of the cAMP-PKA pathway antagonizes metformin suppression of hepatic glucose production
L He, E Chang, J Peng, H An, SM McMillin… - Journal of Biological …, 2016 - ASBMB
Metformin is the most commonly prescribed oral anti-diabetic agent worldwide. Surprisingly,
about 35% of diabetic patients either lack or have a delayed response to metformin
treatment, and many patients become less responsive to metformin over time. It remains
unknown how metformin resistance or insensitivity occurs. Recently, we found that
therapeutic metformin concentrations suppressed glucose production in primary
hepatocytes through AMPK; activation of the cAMP-PKA pathway negatively regulates …
about 35% of diabetic patients either lack or have a delayed response to metformin
treatment, and many patients become less responsive to metformin over time. It remains
unknown how metformin resistance or insensitivity occurs. Recently, we found that
therapeutic metformin concentrations suppressed glucose production in primary
hepatocytes through AMPK; activation of the cAMP-PKA pathway negatively regulates …