[HTML][HTML] The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation

MA Rishavy, KW Hallgren, LA Wilson… - Journal of Biological …, 2013 - ASBMB
The vitamin K oxidoreductase (VKORC1) recycles vitamin K to support the activation of
vitamin K-dependent (VKD) proteins, which have diverse functions that include hemostasis
and calcification. VKD proteins are activated by Glu carboxylation, which depends upon the
oxygenation of vitamin K hydroquinone (KH 2). The vitamin K epoxide (KO) product is
recycled by two reactions, ie KO reduction to vitamin K quinone (K) and then to KH 2, and
recent studies have called into question whether VKORC1 reduces K to KH 2. Analysis in …