The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular
responses. These receptors appear to largely account for the cellular effects of thrombin and
can mediate signaling to other trypsin‐like proteases. An important role for PARs in
hemostasis and thrombosis is established in animal models, and studies in knockout mice
and nonhuman primates raise the question of whether PAR inhibition might offer an …