[HTML][HTML] Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies
M Sips, M Krykbaeva, TJ Diefenbach… - Mucosal …, 2016 - Elsevier
Although the development of a fully protective HIV vaccine is the ultimate goal of HIV
research, to date only one HIV vaccine trial, the RV144, has successfully induced a weakly
protective response. The 31% protection from infection achieved in the RV144 trial was
linked to the induction of nonneutralizing antibodies, able to mediate antibody-dependent
cell-mediated cytotoxicity (ADCC), suggestive of an important role of Fc-mediated functions
in protection. Similarly, Fc-mediated antiviral activity was recently shown to play a critical …
research, to date only one HIV vaccine trial, the RV144, has successfully induced a weakly
protective response. The 31% protection from infection achieved in the RV144 trial was
linked to the induction of nonneutralizing antibodies, able to mediate antibody-dependent
cell-mediated cytotoxicity (ADCC), suggestive of an important role of Fc-mediated functions
in protection. Similarly, Fc-mediated antiviral activity was recently shown to play a critical …