Interactions between human immunodeficiency virus type 1 and polymorphonuclear neutrophils

S Casulli, C Elbim - Journal of innate immunity, 2014 - karger.com
S Casulli, C Elbim
Journal of innate immunity, 2014karger.com
Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They
represent a first line of innate immunity against a large panel of microbial pathogens,
pending development of specific immune responses. The role of PMN in human
immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point
of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal
infections. However, it is now clear that the relationship between PMN and HIV-1 is far more …
Abstract
Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.
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