[HTML][HTML] Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells
Plasmacytoid dendritic cells (PDC) represent the main type I interferon (IFN-I) producing
cells. Emerging evidence supports a role for IFN-I in autoimmune diseases. Given the
central role of PDC in the pathogenesis of systemic lupus erythematosus (SLE), we
investigated the effect of Trichostatin A (TSA), a prototypic histone deacetylase inhibitor, on
PDC activation. TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory
cytokines TNFα and IL-6 by CpG-activated PDC. These effects were associated with the …
cells. Emerging evidence supports a role for IFN-I in autoimmune diseases. Given the
central role of PDC in the pathogenesis of systemic lupus erythematosus (SLE), we
investigated the effect of Trichostatin A (TSA), a prototypic histone deacetylase inhibitor, on
PDC activation. TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory
cytokines TNFα and IL-6 by CpG-activated PDC. These effects were associated with the …