[HTML][HTML] Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature
MJ Wang, YY Xu, RY Huang, XM Chen, HM Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
MJ Wang, YY Xu, RY Huang, XM Chen, HM Chen, L Han, YH Yan, CJ Lu
Oncotarget, 2017•ncbi.nlm.nih.govBACKGROUND Specific profile of microRNAs (miRNAs, miR) expressed in psoriasis has
been identified in the past few years, while the studies on roles and molecular mechanisms
of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31,
miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic
lesions. We therefore conducted a systematic literature review in this study to reveal the role
of these miRNAs in the pathogenesis of psoriasis in order to inform future research …
been identified in the past few years, while the studies on roles and molecular mechanisms
of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31,
miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic
lesions. We therefore conducted a systematic literature review in this study to reveal the role
of these miRNAs in the pathogenesis of psoriasis in order to inform future research …
Abstract
BACKGROUND
Specific profile of microRNAs (miRNAs, miR) expressed in psoriasis has been identified in the past few years, while the studies on roles and molecular mechanisms of these miRNAs are still on the way. In our previous study, four specific miRNAs (miR-31, miR-203, hsa-miR-99a and miR-125b) were found to be specifically altered in psoriatic lesions. We therefore conducted a systematic literature review in this study to reveal the role of these miRNAs in the pathogenesis of psoriasis in order to inform future research.
METHODS
The related articles indexed in PubMed (MEDLINE) database were searched and analyzed. We identified eligible studies related to the mechanism research of miR-31, miR-203, hsa-miR-99a and miR-125b in psoriasis or psoriatic lesional skin from inception up to July 2016. The experts in the field of miRNAs and Psoriasis were involved in analysis process.
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