Over the last few years it has become clear that a proportion of biopsies from patients with
Duchenne muscular dystrophy (DMD) contain fibres which show dystrophin-positive
immunolabelling. We have collected evidence to demonstrate that low level restoration of
the reading frame must have been taking place and that a BMD-like protein was being
synthesized in DMD muscle. We have also found a relationship between the abundance of
dystrophin (determined by densitometric analysis of blots) and the age at which boys lose …