Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom)

P Gao, T Hirano, Z Chen, T Yasuhara, Y Nakata… - Fitoterapia, 2012 - Elsevier
We previously showed that ethanolic extracts of spores of Ganoderma lucidum inhibit tumor
cell proliferation and induce apoptosis of HL-60 cells. The active constituents appeared to
be long-chain fatty acids, particularly carbon-19 (C-19) fatty acids which have not been
reported in spores of Ganoderma lucidum. In the present study, two of these C-19 fatty acids
which are key compounds in the activities, were identified as their 2-naphthyl ester
derivatives after esterification of a mixture of fatty acids obtained from the spores. The active …