[HTML][HTML] Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear …
C Weigert, K Brodbeck, H Staiger, C Kausch… - Journal of Biological …, 2004 - ASBMB
Circulating interleukin-6 (IL-6), insulin, and free fatty acid (FFA) concentrations are
associated with impaired insulin action in obese and type 2 diabetic individuals. However, a
causal relationship between elevated plasma FFAs and IL-6 has not been shown. Because
skeletal muscle represents a major target of impaired insulin action, we studied whether
FFAs may affect IL-6 expression in human myotubes. We demonstrate that specifically
saturated FFAs, eg palmitate (0.25 mm), induce IL-6 mRNA expression and protein secretion …
associated with impaired insulin action in obese and type 2 diabetic individuals. However, a
causal relationship between elevated plasma FFAs and IL-6 has not been shown. Because
skeletal muscle represents a major target of impaired insulin action, we studied whether
FFAs may affect IL-6 expression in human myotubes. We demonstrate that specifically
saturated FFAs, eg palmitate (0.25 mm), induce IL-6 mRNA expression and protein secretion …