[HTML][HTML] The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells
The early growth response-1 gene (EGR-1) is induced by a wide range of stimuli in diverse
cell types; however, EGR-1-regulated genes display a highly restricted pattern of
expression. Recently, an overlapping Sp1· EGR-1 binding site has been identified within the
interleukin-2 (IL-2) gene promoter directly upstream of the binding site for the nuclear factor
of activated T cells (NFAT). We used transfection assays to study how the abundantly and
constitutively expressed Sp1 protein and the immediate early EGR-1 zinc finger protein …
cell types; however, EGR-1-regulated genes display a highly restricted pattern of
expression. Recently, an overlapping Sp1· EGR-1 binding site has been identified within the
interleukin-2 (IL-2) gene promoter directly upstream of the binding site for the nuclear factor
of activated T cells (NFAT). We used transfection assays to study how the abundantly and
constitutively expressed Sp1 protein and the immediate early EGR-1 zinc finger protein …