[HTML][HTML] Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
R Bucala, LA Spiegel, J Chesney, M Hogan… - Molecular …, 1994 - Springer
R Bucala, LA Spiegel, J Chesney, M Hogan, A Cerami
Molecular medicine, 1994•SpringerBackground The host response to tissue injury requires a complex interplay of diverse
cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by
proliferating within injured sites and contributing to scar formation and the long-term
remodeling of damaged tissue. Fibroblasts present in areas of tissue injury generally have
been regarded to arise by recruitment from surrounding connective tissue; however this may
not be the only source of these cells. Materials and Methods Long-term culture of adherent …
cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by
proliferating within injured sites and contributing to scar formation and the long-term
remodeling of damaged tissue. Fibroblasts present in areas of tissue injury generally have
been regarded to arise by recruitment from surrounding connective tissue; however this may
not be the only source of these cells. Materials and Methods Long-term culture of adherent …
Background
The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this process by proliferating within injured sites and contributing to scar formation and the long-term remodeling of damaged tissue. Fibroblasts present in areas of tissue injury generally have been regarded to arise by recruitment from surrounding connective tissue; however this may not be the only source of these cells.
Materials and Methods
Long-term culture of adherent, human, and murine leukocyte subpopulations was combined with a variety of immunofluorescence and functional analyses to identify a blood-borne cell type with fibroblast-like properties.
Results
We describe for the first time a population of circulating cells with fibroblast properties that specifically enter sites of tissue injury. This novel cell type, termed a “fibrocyte,” was characterized by its distinctive phenotype (collagen+/vimentin+/CD34+), by its rapid entry from blood into subcutaneously implanted wound chambers, and by its presence in connective tissue scars.
Conclusions
Blood-borne fibrocytes contribute to scar formation and may play an important role both in normal wound repair and in pathological fibrotic responses.
Springer