Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the …
K Szczepanek, Q Chen, M Derecka, FN Salloum… - Journal of Biological …, 2011 - ASBMB
Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases
the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides
in the mitochondria where it is necessary for the maximal activity of complexes I and II of the
electron transport chain. However, it has not been explored whether mitochondrial STAT3
modulates cardiac function under conditions of stress. Transgenic mice with cardiomyocyte-
specific overexpression of mitochondria-targeted STAT3 with a mutation in the DNA-binding …
the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides
in the mitochondria where it is necessary for the maximal activity of complexes I and II of the
electron transport chain. However, it has not been explored whether mitochondrial STAT3
modulates cardiac function under conditions of stress. Transgenic mice with cardiomyocyte-
specific overexpression of mitochondria-targeted STAT3 with a mutation in the DNA-binding …
