[HTML][HTML] Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing …
S Wu, T Grunwald, A Kharitonenkov, J Dam… - Journal of Biological …, 2013 - ASBMB
During calorie restriction in mice, increased expression of FGF21 causes growth attenuation
and growth hormone (GH) insensitivity. Previous evidence also indicates that fasting-
associated increased expression of leptin receptor overlapping transcript (LEPROT) and
LEPROT-like 1 (LEPROTL1)(two proteins that regulate intracellular protein trafficking)
reduces GH receptor cell-surface expression in the liver. Thus, we hypothesized that FGF21
causes GH insensitivity through regulation of LEPROT and/or LEPROTL1 expression. After 4 …
and growth hormone (GH) insensitivity. Previous evidence also indicates that fasting-
associated increased expression of leptin receptor overlapping transcript (LEPROT) and
LEPROT-like 1 (LEPROTL1)(two proteins that regulate intracellular protein trafficking)
reduces GH receptor cell-surface expression in the liver. Thus, we hypothesized that FGF21
causes GH insensitivity through regulation of LEPROT and/or LEPROTL1 expression. After 4 …