The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
J Henderson, K Northstone, SP Lee, H Liao… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Atopic disease is a major health problem. Mutations in the filaggrin gene
(FLG) confer major susceptibility to eczema and related asthma. OBJECTIVE: We sought to
determine the natural history and burden of atopic disease conferred by the 2 most common
FLG mutations in a large, population-based birth cohort study. METHODS: We analyzed the
effect of the most common null alleles (R501X and 2282del4) on several atopic phenotypes
in a cohort of approximately 7000 English children born in 1990-1991. RESULTS: FLG null …
(FLG) confer major susceptibility to eczema and related asthma. OBJECTIVE: We sought to
determine the natural history and burden of atopic disease conferred by the 2 most common
FLG mutations in a large, population-based birth cohort study. METHODS: We analyzed the
effect of the most common null alleles (R501X and 2282del4) on several atopic phenotypes
in a cohort of approximately 7000 English children born in 1990-1991. RESULTS: FLG null …