B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function
R Sodi, E Dubuis, A Shenkin, G Hart - Regulatory peptides, 2008 - Elsevier
A fundamental question in physiology is how hormones regulate the functioning of a cell or
organ. It was therefore the aim of this study to investigate the effect (s) of BNP-32 on calcium
handling by ventricular myocytes obtained from the rat left ventricle. We specifically tested
the hypothesis that BNP-32 decreased the L-type calcium current (ICa, L). Perforated patch
clamp technique was used to record ICa, L and action potential (AP) in voltage and current
clamp mode, respectively. Myocyte shortening was measured using a photodiode array …
organ. It was therefore the aim of this study to investigate the effect (s) of BNP-32 on calcium
handling by ventricular myocytes obtained from the rat left ventricle. We specifically tested
the hypothesis that BNP-32 decreased the L-type calcium current (ICa, L). Perforated patch
clamp technique was used to record ICa, L and action potential (AP) in voltage and current
clamp mode, respectively. Myocyte shortening was measured using a photodiode array …