[HTML][HTML] Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients
MV Mashikian, RE Tarpy, JJ Saukkonen, KG Lim… - Journal of allergy and …, 1998 - Elsevier
Objective: We have previously demonstrated that the earliest lymphocyte chemotactic factors
present in bronchoalveolar lavage fluid (BALF) of subjects with atopic asthma after
subsegmental antigen challenge are IL-16 and MIP-1α, of which IL-16 appears to contribute
a majority of the chemotactic activity. Because IL-16 is released in vitro after histamine
stimulation of CD8+ T cells and epithelial cells, we evaluated the potential role of histamine
in the release of IL-16 into the airways of allergic asthmatics in vivo. Methods: Eight allergic …
present in bronchoalveolar lavage fluid (BALF) of subjects with atopic asthma after
subsegmental antigen challenge are IL-16 and MIP-1α, of which IL-16 appears to contribute
a majority of the chemotactic activity. Because IL-16 is released in vitro after histamine
stimulation of CD8+ T cells and epithelial cells, we evaluated the potential role of histamine
in the release of IL-16 into the airways of allergic asthmatics in vivo. Methods: Eight allergic …
