Phage display has been used as a powerful tool in the discovery and characterization of
ligand–receptor complexes that can be utilized for therapeutic applications as well as to
elucidate disease mechanisms. While the basic properties of phage itself have been well
described, the behavior of phage in an in vivo setting is not as well understood due to the
complexity of the system. Here, we take a dual approach in describing the biophysical
mechanisms and properties that contribute to the efficacy of in vivo phage targeting. We …