A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice
GG de Ridder, R Ray, SV Pizzo - Melanoma research, 2012 - journals.lww.com
The HSP70 family member GRP78 is a selective tumor marker upregulated on the surface of
many tumor cell types, including melanoma, where it acts as a growth factor receptor-like
protein. Receptor-recognized forms of the proteinase inhibitor α 2-macroglobulin (α 2 M*)
are the best-characterized ligands for GRP78, but in melanoma and other cancer patients,
autoantibodies arise against the NH 2-terminal domain of GRP78 that react with tumor cell-
surface GRP78. This causes the activation of signaling cascades that are proproliferative …
many tumor cell types, including melanoma, where it acts as a growth factor receptor-like
protein. Receptor-recognized forms of the proteinase inhibitor α 2-macroglobulin (α 2 M*)
are the best-characterized ligands for GRP78, but in melanoma and other cancer patients,
autoantibodies arise against the NH 2-terminal domain of GRP78 that react with tumor cell-
surface GRP78. This causes the activation of signaling cascades that are proproliferative …