[HTML][HTML] A new tumor-specific variant of GRP78 as target for antibody-based therapy

N Rauschert, S Brändlein, E Holzinger, F Hensel… - Laboratory …, 2008 - Elsevier
The chaperone GRP78 is a member of the heat-shock protein 70 (HSP70) family and is
responsible for cellular homeostasis by preventing stress-induced apoptosis. GRP78 is
expressed in all cells of the body. In malignant cells, which are permanently exposed to
environmental stress, GRP78 is overexpressed and increased levels can be found in the
cytoplasm and on the cell membrane. Thus, GRP78 promotes tumor proliferation, survival,
metastases and resistance to a wide variety of therapies. Like other tumor-specific …