The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model
M McDonnold, E Tamayo, T Kechichian… - American journal of …, 2014 - Elsevier
Objective Preeclampsia alters fetal programming and results in long-term metabolic
consequences in the offspring. Pravastatin has been shown to prevent preeclampsia in
animal models. Our aim was to characterize the effects of preeclampsia on fetal
programming of adult growth and metabolic function, and evaluate the role of preventive
pravastatin therapy, using a well characterized murine model. Study Design CD-1 mice were
injected through the tail vein with adenovirus carrying soluble fms-like tyrosine kinase 1 (sFlt …
consequences in the offspring. Pravastatin has been shown to prevent preeclampsia in
animal models. Our aim was to characterize the effects of preeclampsia on fetal
programming of adult growth and metabolic function, and evaluate the role of preventive
pravastatin therapy, using a well characterized murine model. Study Design CD-1 mice were
injected through the tail vein with adenovirus carrying soluble fms-like tyrosine kinase 1 (sFlt …