Prepregnancy obesity and sFlt1-induced preeclampsia in mice: developmental programming model of metabolic syndrome
E Bytautiene, E Tamayo, T Kechichian, N Drever… - American journal of …, 2011 - Elsevier
Objective We sought to establish a model of fetal programming of metabolic syndrome by
exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and
preexisting maternal obesity (MO). Study design CD-1 female mice were placed on either
standard or high-fat diet for 3 months. On day 8 of pregnancy, mice were injected with either
adenovirus-carrying sFlt1 or adenovirus-carrying murine immunoglobulin G2α Fc fragment.
Offspring were studied at 6 months of age. Results Exposure to MO with/without PE resulted …
exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and
preexisting maternal obesity (MO). Study design CD-1 female mice were placed on either
standard or high-fat diet for 3 months. On day 8 of pregnancy, mice were injected with either
adenovirus-carrying sFlt1 or adenovirus-carrying murine immunoglobulin G2α Fc fragment.
Offspring were studied at 6 months of age. Results Exposure to MO with/without PE resulted …