In utero programming of chronic disease.
DJ Barker - Clinical science (London, England: 1979), 1998 - europepmc.org
DJ Barker
Clinical science (London, England: 1979), 1998•europepmc.org1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they
permanently change their structure and metabolism. 2. These'programmed'changes may be
the origins of a number of diseases in later life, including coronary heart disease and the
related disorders stroke, diabetes and hypertension. 3. This review examines the evidence
linking these diseases to fetal undernutrition and provides an overview of previous studies in
this area.
permanently change their structure and metabolism. 2. These'programmed'changes may be
the origins of a number of diseases in later life, including coronary heart disease and the
related disorders stroke, diabetes and hypertension. 3. This review examines the evidence
linking these diseases to fetal undernutrition and provides an overview of previous studies in
this area.
1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These'programmed'changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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