Quantifying the effect of changes in the hemodialysis prescription on effective solute removal with a mathematical model
WR Clark, JK Leypoldt, LW Henderson… - Journal of the …, 1999 - journals.lww.com
One potential benefit of chronic hemodialysis (HD) regimens of longer duration or greater
frequency than typical three-times-weekly schedules is enhanced solute removal over a
relatively wide molecular weight spectrum of uremic toxins. This study assesses the effect of
variations in HD frequency (F: per week), duration (T: min per treatment), and
blood/dialysate flow rates (QB/QD: ml/min) on steady-state concentration profiles of five
surrogates: urea (U), creatinine (Cr), vancomycin (V), inulin (I), and β 2-microglobulin (β2M) …
frequency than typical three-times-weekly schedules is enhanced solute removal over a
relatively wide molecular weight spectrum of uremic toxins. This study assesses the effect of
variations in HD frequency (F: per week), duration (T: min per treatment), and
blood/dialysate flow rates (QB/QD: ml/min) on steady-state concentration profiles of five
surrogates: urea (U), creatinine (Cr), vancomycin (V), inulin (I), and β 2-microglobulin (β2M) …