[HTML][HTML] Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration
PA Vanlandingham, BP Ceresa - Journal of Biological Chemistry, 2009 - ASBMB
The small molecular weight G-protein RAB7 is localized to both early and late endosomes
and has been shown to be critical for trafficking through the endocytic pathway. The role of
RAB7 in the endocytic pathway has been controversial, with some groups reporting that it
regulates trafficking from early to late endosomes and others ascribing its role to trafficking
between late endosomes and lysosomes. In this study, we use RNA interference to identify
the exact step RAB7 regulates in the movement of the epidermal growth factor receptor …
and has been shown to be critical for trafficking through the endocytic pathway. The role of
RAB7 in the endocytic pathway has been controversial, with some groups reporting that it
regulates trafficking from early to late endosomes and others ascribing its role to trafficking
between late endosomes and lysosomes. In this study, we use RNA interference to identify
the exact step RAB7 regulates in the movement of the epidermal growth factor receptor …