[HTML][HTML] Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium

M Alfaidi, H Wilson, M Daigneault, A Burnett… - Journal of Biological …, 2015 - ASBMB
The endothelium is critically involved in the pathogenesis of atherosclerosis by producing
pro-inflammatory mediators, including IL-1β. Coronary arteries from patients with ischemic
heart disease express large amounts of IL-1β in the endothelium. However, the mechanism
by which endothelial cells (ECs) release IL-1β remains to be elucidated. We investigated
neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human
carotid plaques, as a potential" trigger" for IL-1β processing and release. This study tested …