Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies
JD Sherrill, ME Rothenberg - Journal of Allergy and Clinical Immunology, 2011 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus that is
compounded by both genetic predisposition and aberrant responses to environmental
antigens, particularly those that are food derived. Data have indicated a unique
transcriptional response in vivo that defines EoE and that appears to be partially attributable
to the TH 2 cytokine IL-13. Moreover, a number of genetic risk variants in proinflammatory
and epithelial cell genes associate with EoE susceptibility, demonstrating novel heritable …
compounded by both genetic predisposition and aberrant responses to environmental
antigens, particularly those that are food derived. Data have indicated a unique
transcriptional response in vivo that defines EoE and that appears to be partially attributable
to the TH 2 cytokine IL-13. Moreover, a number of genetic risk variants in proinflammatory
and epithelial cell genes associate with EoE susceptibility, demonstrating novel heritable …