Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis
Background Mast cells derive from hematopoietic cell precursors and participate in tissue
allergic, immune, and inflammatory processes. They secrete many mediators, including
preformed TNF, in response to allergic, neuropeptide, and environmental triggers. However,
regulation of mast cell degranulation is not well understood. Objective We investigated the
role of mitochondrial dynamics in degranulation of human cultured mast cells. Methods
Human umbilical cord blood–derived mast cells (hCBMCs) and Laboratory of Allergic …
allergic, immune, and inflammatory processes. They secrete many mediators, including
preformed TNF, in response to allergic, neuropeptide, and environmental triggers. However,
regulation of mast cell degranulation is not well understood. Objective We investigated the
role of mitochondrial dynamics in degranulation of human cultured mast cells. Methods
Human umbilical cord blood–derived mast cells (hCBMCs) and Laboratory of Allergic …