Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction
SS Aceves, D Chen, RO Newbury, R Dohil… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Increased numbers of mast cells are present in the esophageal epithelium
in patients with eosinophilic esophagitis (EE). However, mast cell infiltration into the
esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on
SM function has not been determined. OBJECTIVE: We investigated mast cell localization
and characterization in esophageal SM, the functional significance of mast cell TGF-β1
expression to contraction of human esophageal smooth muscle (HESM) cells in vitro, and …
in patients with eosinophilic esophagitis (EE). However, mast cell infiltration into the
esophageal lamina propria (LP) and smooth muscle (SM) and the effects of their products on
SM function has not been determined. OBJECTIVE: We investigated mast cell localization
and characterization in esophageal SM, the functional significance of mast cell TGF-β1
expression to contraction of human esophageal smooth muscle (HESM) cells in vitro, and …