High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders

JP Abonia, T Wen, EM Stucke, T Grotjan… - Journal of allergy and …, 2013 - Elsevier
Background Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease
mediated by immune hypersensitization to multiple foods and strongly associated with atopy
and esophageal remodeling. Objective We provide clinical and molecular evidence
indicating a high prevalence of EoE in patients with inherited connective tissue disorders
(CTDs). Methods We examined the rate of EoE among patients with CTDs and subsequently
analyzed esophageal mRNA transcript profiles in patients with EoE with or without CTD …