[HTML][HTML] Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation
M Rochman, AV Kartashov, JM Caldwell, MH Collins… - Mucosal …, 2015 - Elsevier
Abstract Although interleukin (IL)-13 and neurotrophins are functionally important for the
pathogenesis of immune responses, the interaction of these pathways has not been
explored. Herein, by interrogating IL-13-induced responses in human epithelial cells we
show that neurotrophic tyrosine kinase receptor, type 1 (NTRK1), a cognate, high-affinity
receptor for nerve growth factor (NGF), is an early transcriptional IL-13 target. Induction of
NTRK1 was accompanied by accumulation of activating epigenetic marks in the promoter; …
pathogenesis of immune responses, the interaction of these pathways has not been
explored. Herein, by interrogating IL-13-induced responses in human epithelial cells we
show that neurotrophic tyrosine kinase receptor, type 1 (NTRK1), a cognate, high-affinity
receptor for nerve growth factor (NGF), is an early transcriptional IL-13 target. Induction of
NTRK1 was accompanied by accumulation of activating epigenetic marks in the promoter; …