Trafficking of leukocytes to sites of inflammation is an important step in the establishment of
an immune response. Chemokines are critical regulators of leukocyte trafficking and are
widely studied molecules for their important role in disease and for their potential as new
therapeutic targets. The ability of chemokines to induce leukocyte recruitment has been
mainly measured by in vitro chemotaxis assays, which lack many components of the
complex biological process of leukocyte migration and therefore provide incomplete …