Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease
C Hermsen, T van de Wiel, E Mommers, R Sauerwein… - Parasitology, 1997 - cambridge.org
C Hermsen, T van de Wiel, E Mommers, R Sauerwein, W Eling
Parasitology, 1997•cambridge.orgThe role of T-cells in development of experimental cerebral malaria was analysed in
C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium
berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against
cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during
infection. Even in mice in end-stage disease, ie with a body temperature below 35· 5° C,
treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM …
C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium
berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against
cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during
infection. Even in mice in end-stage disease, ie with a body temperature below 35· 5° C,
treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM …
The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body temperature below 35·5 °C, treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM, whereas chloroquine treatment was completely ineffective in inhibiting further development of the cerebral syndrome.
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