[HTML][HTML] Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner

A Padmanabhan, X Li, CJ Bieberich - Journal of Biological Chemistry, 2013 - ASBMB
MYC levels are tightly regulated in cells, and deregulation is associated with many cancers.
In this report, we describe the existence of a MYC-protein kinase A (PKA)-polo-like kinase 1
(PLK1) signaling loop in cells. We report that sequential MYC phosphorylation by PKA and
PLK1 protects MYC from proteasome-mediated degradation. Interestingly, short term pan-
PKA inhibition diminishes MYC level, whereas prolonged PKA catalytic subunit α (PKACα)
knockdown, but not PKA catalytic subunit β (PKACβ) knockdown, increases MYC. We show …