[HTML][HTML] A Good Manufacturing Practice–grade standard protocol for exclusively human mesenchymal stromal cell–derived extracellular vesicles
K Pachler, T Lener, D Streif, ZA Dunai, A Desgeorges… - Cytotherapy, 2017 - Elsevier
Abstract Background aims Extracellular vesicles (EVs) released by mesenchymal stromal
cells (MSCs) may contribute to biological processes such as tissue regeneration,
immunomodulation and neuroprotection. Evaluation of their therapeutic potential and
application in future clinical trials demands thorough characterization of EV content and
production under defined medium conditions, devoid of xenogenic substances and serum-
derived vesicles. Addressing the apparent need for such a growth medium, we have …
cells (MSCs) may contribute to biological processes such as tissue regeneration,
immunomodulation and neuroprotection. Evaluation of their therapeutic potential and
application in future clinical trials demands thorough characterization of EV content and
production under defined medium conditions, devoid of xenogenic substances and serum-
derived vesicles. Addressing the apparent need for such a growth medium, we have …