Endocrine function of the pancreas in cystic fibrosis: evidence for an impaired glucagon and insulin response following arginine infusion
M Stahl, J Girard, M Rutishauser, PW Nars… - The Journal of …, 1974 - Elsevier
M Stahl, J Girard, M Rutishauser, PW Nars, K Zuppinger
The Journal of pediatrics, 1974•ElsevierPancreatic glucagon and insulin were determined in 10 children with cystic fibrosis (CF) and
in a control group following stimulation by an arginine infusion. In controls the infusion of
arginine induced a prompt threefold elevation in plasma pancreatic glucagon and about a
sixfold increase in plasma immunoreactive insulin. In patients with CF the average response
of both hormones was considerably less, and the base-line concentrations for glucagon
were lower. The data support the hypothesis that in CF both alpha-and beta-cell function are …
in a control group following stimulation by an arginine infusion. In controls the infusion of
arginine induced a prompt threefold elevation in plasma pancreatic glucagon and about a
sixfold increase in plasma immunoreactive insulin. In patients with CF the average response
of both hormones was considerably less, and the base-line concentrations for glucagon
were lower. The data support the hypothesis that in CF both alpha-and beta-cell function are …
Pancreatic glucagon and insulin were determined in 10 children with cystic fibrosis (C.F.) and in a control group following stimulation by an arginine infusion. In controls the infusion of arginine induced a prompt threefold elevation in plasma pancreatic glucagon and about a sixfold increase in plasma immunoreactive insulin. In patients with C.F. the average response of both hormones was considerably less, and the base-line concentrations for glucagon were lower. The data support the hypothesis that in C.F. both alpha- and beta-cell function are affected as a result of the underlying process.
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