[HTML][HTML] A prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4α that regulates the cholesterol 7α-hydroxylase gene
Prox1, an early specific marker for developing liver and pancreas in foregut endoderm has
recently been shown to interact with α-fetoprotein transcription factor and repress cholesterol
7α-hydroxylase (CYP7A1) gene transcription. Using a yeast two-hybrid assay, we found that
Prox1 strongly and specifically interacted with hepatocyte nuclear factor (HNF) 4α, an
important transactivator of the human CYP7A1 gene in bile acid synthesis and
phosphoenolpyruvate carboxykinase (PEPCK) gene in gluconeogenesis. A real time PCR …
recently been shown to interact with α-fetoprotein transcription factor and repress cholesterol
7α-hydroxylase (CYP7A1) gene transcription. Using a yeast two-hybrid assay, we found that
Prox1 strongly and specifically interacted with hepatocyte nuclear factor (HNF) 4α, an
important transactivator of the human CYP7A1 gene in bile acid synthesis and
phosphoenolpyruvate carboxykinase (PEPCK) gene in gluconeogenesis. A real time PCR …