[HTML][HTML] Evasion of host immune defenses by human papillomavirus

JA Westrich, CJ Warren, D Pyeon - Virus research, 2017 - Elsevier
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as
well as physical barriers, have been implicated in controlling early HPV infections. However,
if HPV overcomes these host immune defenses and establishes persistence in basal
keratinocytes, it becomes very difficult for the host to eliminate the infection. The HPV
oncoproteins E5, E6, and E7 are important in regulating host immune responses. These …