HPV-associated head and neck cancer: unique features of epidemiology and clinical management
JH Maxwell, JR Grandis, RL Ferris - Annual review of medicine, 2016 - annualreviews.org
Human papillomavirus (HPV) is a recently identified causative agent for a subset of head
and neck cancers, primarily in the oropharynx, and is largely responsible for the rising
worldwide incidence of oropharyngeal cancer (OPC). Patients with HPV-positive OPC have
distinct risk factor profiles and generally have a better prognosis than patients with
traditional, HPV-negative, head and neck cancer. Concurrent chemotherapy and radiation is
a widely accepted primary treatment modality for many patients with HPV-positive OPC …
and neck cancers, primarily in the oropharynx, and is largely responsible for the rising
worldwide incidence of oropharyngeal cancer (OPC). Patients with HPV-positive OPC have
distinct risk factor profiles and generally have a better prognosis than patients with
traditional, HPV-negative, head and neck cancer. Concurrent chemotherapy and radiation is
a widely accepted primary treatment modality for many patients with HPV-positive OPC …